FOR PROFESSIONAL USE ONLY

 

 

Product Description:

Hyalegend^TM is a joint lubricant to support joint health. An anti-inflammatory agent for articular disorders in horses particularly those in competition or heavy work. It is indicated for carpal and fetlock joint dysfunctions, but not when joint sepsis or fracture are suspected. It is especially used for synovitis associated with horses’ osteoarthritis. It can be administered directly into an affected joint for more localized disorders or intravenous.

 

 

Active Ingredient:

Hyaluronate Sodium ………………………………………………………………………………… 10 mg/ml

 

Hyaluronic acid is the conjugate acid of hyaluronate sodium, also called hyaluronan. It is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans as nonsulfated. It forms in the plasma membrane instead of the Golgi apparatus, and it can be very large. 

Hyaluronic acid is an important component of articular cartilage, where it is present as a coat around each cell (chondrocyte). Normal joints have pads of cartilage protecting the ends of the bones that form the joint and a surrounding capsule lined by a membrane that is active in maintaining healthy joint functions. Hyaluronic acid is a proteoglycan, an organic chemical composed of protein and carbohydrate molecules, and is manufactured by the synovial lining of the joint and by the cells that manufacture cartilage. 

Hyaluronic acid forms a thin coating on articular cartilage and is a component of joint fluid.

 

How It Works:

Hyaluronic acid is a major component of the synovial fluid and was found to increase the viscosity of the fluid. Along with lubricin, it is one of the fluid’s main lubricating components. Hyaluronic acid is an important component of articular cartilage, where it is present as a coat around each cell (chondrocyte). When aggrecan monomers bind to hyaluronate sodium in the presence of HAPLN1 (hyaluronic acid and proteoglycan link protein 1), large, highly negatively charged aggregates form. These aggregates imbibe water and are responsible for the resilience of cartilage (its resistance to compression). The molecular weight (size) of hyaluronate sodium in cartilage decreases with age, but the amount increases. A lubricating role of hyaluronate sodium in muscular connective tissues to enhance the sliding between adjacent tissue layers has been suggested. A particular type of fibroblasts, embedded in dense fascial tissues, has been proposed as being cells specialized for the biosynthesis of the hyaluronate sodium-rich matrix. Their related activity could be involved in regulating the sliding ability between adjacent muscular connective tissues. While it is abundant in extracellular matrices, hyaluronate sodium also contributes to tissue hydrodynamics, movement, and proliferation of cells, and participates in a number of cell surface receptor interactions, notably those including its primary receptors, CD44 and RHAMM. Upregulation of CD44 itself is widely accepted as a marker of cell activation in lymphocytes. Hyaluronic acid’s contribution to tumor growth may be due to its interaction with CD44. Receptor CD44 participates in cell adhesion interactions required by tumor cells. Although hyaluronate sodium binds to receptor CD44, there is evidence hyaluronate sodium degradation products transduce their inflammatory signal through toll-like receptor 2 (TLR2), TLR4, or both TLR2 and TLR4 in macrophages and dendritic cells. TLR and hyaluronate sodium play a role in innate immunity. There are limitations including the in vivo loss of this compound limiting the duration of effect.

Hyaluronate sodium is naturally found in all living organisms and has a number of functions in the body. High concentrations of hyaluronate sodium are found in the synovial fluid of a joint. Molecular chains bind together and restore the synovial fluid to protect the joint from a continuous inflammatory assault of destructive enzymes released from white blood cells. Hyaluronate acid exerts an anti-inflammatory action by inhibiting the movement of granulocytes and macrophages.

 

Hyalegend^TM is a solution that aids in non-infectious joint dysfunction in horses.

 

Indications:  

For use by or under the direction of a registered veterinarian in the cases of:

• Lubricates joint tissues.
• Improves joint motion.
• Reduces joint friction.
• Aids Non-infectious synovitis in horse.

 

 

Dosage and Administration:

Intravenous method:

For intravenous administration use 4 ml for 450 kg animal at 5-7 days intervals for a total of 3 administrations, and then once a month or 48 hours before competitions.

Intra-articular method:     

Administer 20 mg by IA administration for small and medium joint sizes (carpal, fetlock), and 40 mg by IA administration for larger joint sizes (hock) by licensed veterinary. These administrations may be repeated at weekly intervals for a total of three administrations. Animals should be given two days stall rest before gradually resuming normal activity.

Radiographic evaluation should be carried out in cases of acute lameness to ensure that the joint is free from serious fractures. As with any intra-articular administration, special precautions must be followed. Intra-articular administrations should not be made through the skin that has been recently fired or blistered, or that has excessive scurf and counterirritant on it.

Intra-articular administration may cause mild heating of the joint if directly administered, but this does not affect the clinical outcome. Intra-articular administration is fully metabolized in less than a week.

There are no known side effects.

 

Supplied: 

4 ml glass vial. 

 

 

Species:

Horses.

 

 

Storage:

Store below 25 C (air conditioning).

Do NOT freeze and protect from light.

 

 

Warning:

Not for human use.

Not for use in animals intended for food.

 

 

CAUTION:

• Use this product by or on the order of a licensed veterinarian.
• The safety of Hyalegend^TM has not been evaluated in breeding stallions, or in breeding, pregnant or lactating mares.
• Please check with the regulations committee before using Hyalegend^TM so to avoid possibly breaking rules and being disqualified. Using Hyalegend^TM in your performance animals at any stage of a competition will all depend on the rules and regulations in place for that competition.
• This product is not intended to diagnose, treat, cure, or prevent any disease.
• Keep this and all medications out of reach of children.

• These statements have not been evaluated by the Food and Drug Administration.

   

FOR VETERINARY USE ONLY